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Analyzing Chromosomes

1859961886
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Analyzing Chromosomes

Analysing Chromosomes is a user-friendly guide to successful techniques in the cytogenetics laboratory. Basic theory is linked with suggestions for suitable protocols. Techniques are explained in an easy to follow step-by-step format. The book also focuses on data interpretation and looks at possible errors and artefacts and provides appropriate trouble shooting advice.

Contents:

INTRODUCING THE CELL
Introduction
The cytoplasm
The nucleus
DNA replication
Mutation and DNA repair
Chromosome organization and structure
Chromosome function


CULTURE OF HUMAN CELLS FOR CHROMOSOMAL ANALYSIS
Introduction
Culture of peripheral blood samples
Culture of cells from amniotic fluid
Culture of chromic villus samples
Solid tissue culture
Culture of bone marrow and leukemic blood
Culture of samples from chronic lymphoid leukaemia and lymphomas
Slide preparation


STAINING AND BANDING OF CHROMOSOME SLIDES
Introduction
Banding techniques and their applications

TYPES OF ABNORMALITIES OBSERVED IN CHROMOSOMES
Introduction
Types of chromosomal changes
Nomenclature for human chromosomes


APPROACHING ANALYSIS
Introduction
Guidelines for the analysis of chromosomes from constitutional studies
Guidelines for the analysis of chromosomes from malignant tissues
Clonal abnormality


CONSTITUTIONAL CHROMOSOME ABNORMALITIES
Introduction
Trisomy 21 - down syndrome
Trisomy 18 - Edward syndrome
Trisomy 13 - Patau syndrome
45,X - Turner syndrome
47, XXY - klinefelter syndrome
46, XXX males
47, XYY
47, XXX
Tripliody
Microdeletion syndromes and chromosomal duplications
Marker chromosomes
Ring chromosomes
Fragile X syndrome


ACQUIRED CHROMOSOME ABNORMALITIES OBSERVES IN MALIGNANCY
Introduction
Classification and clinical symptoms of myeloid malignancies
Chromosomal abnormalities observed in acute myeloid leukaemia
Chromosome changes in myelodysplastic syndromes
Chromosome changes in myeloproliferative disorders
Acute lymphoblastic leukaemia
Chronic lymphoproliferative disorders and lymphomas
solid tumors
Summary


NEW COMPLEMENTARY TECHNIQUES
Introduction
Fluorescence in situ hybridization
Twenty-four color painting
Color banding
Primed in situ hybridization
Fiber FISH
Comparative genomic hybridization
The present and future of cytogenetics

Author: B Czepulkowski

ISBN: 1859961886

Pages: 210
Price: Rs.595/-

Author B Czepulkowski
Publisher Ane
Page count 210

Categories: Biological Science

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