An Introduction To Systems Biology

Design Principles Of Biological Circuits.
This is a remarkable book that introduces not only a field but a way of thinking. Uri Alon describes in an elegant, simple way how principles such as stability, robustness and optimal design can be used to analyze and understand the evolution and behavior of living organisms.

SKU1584886420
An Introduction To Systems Biology

Overview

An Introduction To Systems Biology

Design Principles Of Biological Circuits

By Uri Alon

Reviews

"...Beyond simply recounting recent results, Alon boldly articulates the basic principles underlying biological circuitry at different levels and shows how powerful they can be in understanding the complexity of living cells. For anyone who wants to understand how a living cell works, but thought they never would, this book is essential."
-Michael B. Elowitz, California Institute of Technology, USA

"Uri Alon offers a highly original perspective on Systems Biology, emphasizing the function of certain simple networks that appear as ubiquitous building blocks of living matter. The quest for simplicity - without losing contact with complex reality - is the only way to uncover the principles organizing biological systems. Alon writes with uncommon lucidity…"
-Boris Shraiman, UCSB, USA

"This is a remarkable book that introduces not only a field but a way of thinking. Uri Alon describes in an elegant, simple way how principles such as stability, robustness and optimal design can be used to analyze and understand the evolution and behavior of living organisms. Alon's clear intuitive language and helpful examples offer - even to a mathematically naive reader - deep mathematical insights into biology. The community has been waiting for this book; it was worth the wait. "
-Galit Lahav, Harvard Medical School, Boston, Massachusetts, USA.

Contents

*Introduction
*Transcription Networks, Basic Concepts
*Auto-Regulation, A Network Motif
*The Feedforward Loop Network Motif
*Temporal Programs And The Global Structure Of Transcription Networks
*Network Motifs In Developmental, Signal-Transduction And Neuronal Networks
*Robustness Of Protein Circuits, The Example Of Bacterial Chemotaxis
*Robust Patterning In Development
*Kinetic Proofreading
*Optimal Gene Circuit Design
*Rules For Gene Regulation Based On Error Minimization
*Epilogue: Simplicity In Biology
*APPENDIX A: The Input-Function of a Gene, Michaelis-Menten and Hill Equations
*APPENDIX B: Multi-Dimensional Input-Functions
*APPENDIX C: Graph Properties of Transcription Networks
*APPENDIX D: Cell-Cell Variability in Gene Expression
*GLOSSARY
*BIBLIOGRAPHY
*INDEX

About The Author :
Professor Uri Alon is at the Weizmann Institute of Science, Rehovot, Israel

Author: Uri Alon

ISBN: 1584886420

Pages: 320
Price: Rs.2609/-

Features

Author
Uri Alon
Publisher
Ane
Page count
320
Rs.2,609
1584886420

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